I've done it a few times, sometimes with intentions of rolling dolo, or having friends not show up or bounce w/ a chick early. I don't know if it was the luck of the draw or what, but I came up big quite a few times dolo...met a few cuties before, had a great time. Really got my vibe in, met up w/ people I already knew.
...A few things to keep in mind
- strike up a conversation within the first 5 minutes with whoever - bartenders, bouncers, random honeys, whoever.
- make sure you're the best dressed in there, not half stepping what-so-ever.
- have an aire about yourself, almost as if you own the joint
- your friends left early, or they're around somewhere. You're never "here alone", never.
...I would only give this advice to Men with unbreakable confidence, though. Because I've seen (or probably been) a few lames in the club by themselves looking helpless.