I never have auto-save on, I learned my lesson from 2K14 and 2K13 (when they first instituted that auto-save crap).
And the updates I'm talking about are those weekly roster update that now include those "gameplay tweaks" that no longer require an update patch.
This was something I discovered every single time, a "gameplay adjustment update" did some really screwed crap to my MyLeague offline files...........it ended up causing all of my MyLeague files to freeze up/crash whenever I simulated a marathon of games.
In other words, most of MyLeague experience resulted in countless frozen loading screens that never unfroze itself.
Once again, auto-save is off......and I have had to reinstall 2K16 about 20-30 times (along with a hard drive rebuild database about 5-6 times in between).
I never had this issue with 2K15, and that was when they brought back the "disable auto-save" feature for the first time in 4 years.