Network , fellas. Have someone review your resume and cover letter.
It happens, just keep applying and make sure you include every single important course, team project, academic accomplishment, etc. My initial resume included what I did in some of my labs, I.e. My hydraulics lab for Fluids, lab for soils, concrete design, etc. Some employers enjoyed hearing what I knew and what theories I could actually apply in real-life. They understand that you can do the math.
My resume has gotten better every year and have excluded those once I've gained actual experience, but I've heard of people applying to over 100 different companies before receiving their first internship. Don't expose your weaknesses (for example, your GPA is real low, just don't include it)
When you say work in labs, you mean we can include the experiments performed? For example, I know next semester in my solids lab, our professor has us make our own lab. That sounds like something good for a résumé
Whatever experiments, tests, calculations, etc. you do in your labs and actually understand what you're doing, include it in your resume.
Make sure you know what you're talking about since they will ask you.
If you include that you're familiar with certain software (CAD, Revit, VISSIM, HCS, Java, matlab, etc.) Make sure you are actually proficient in them or just don't mention it at all. Or make sure you get proficient in them.