Hide Ya Wives, Hide Ya Kids: Worldwide Coronavirus Pandemic!

Are You Getting The Covid Vaccine?

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  • Only if mandatory

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Where does the spike protein used in the vaccine come from and what is it attached to in order to enter the body?
The question about the ingredients/chemicals is still there though. Have they been used in other vaccines in the past?
B boris already answered this but just to elaborate a couple points -- a virus is typically DNA (or sometimes RNA) that is coated in protein that allows it to invade cells. Once inside, the DNA can hijack your cell's machinery to make a ton of copies of the virus (DNA + protein capsid). Our immune systems try to recognize specific sequences in the protein capsid. Once they've learned a specific sequence, immune cells are very efficient at eliminating virus before it can infect cells and spread in your body.

Protein synthesis normally goes from DNA -> RNA -> protein. With the mRNA vaccine, we are jumping the line and giving just the RNA, but not all the RNA, just a specific piece that is the spike protein. This has the nice advantage that the RNA can't replicate itself, so it's one-and-done. It'll produce some protein in your body, just enough that your immune system can learn some specific sequence that'll let it eliminate the entire virus should you encounter it.

Normally if you inject RNA in your body, it will never make it into a cell. It isn't stable enough and won't cross the cell barrier. Instead, as Boris said, pharmaceutical companies and scientists have figured out a way to package the mRNA in a fatty capsule that is stable and efficiently carries the mRNA into cells.

As for your other question -- yes. There have been dozens (and now over a hundred) trials using mRNA vaccines. Moderna has been working on their fatty capsule for a long time and done lots of clinical trials to choose the optimal formulation. So this has been tested for years already, under very close FDA supervision.
 
The vaccine delivers mRNA wrapped in a fatty capsule to your cells. The fatty capsule is just to protect the mRNA so that it can be successfully delivered to your cells. Once the mRNA is inside your cells, it provides the instructions for your cells to make the spike protein.
B boris already answered this but just to elaborate a couple points -- a virus is typically DNA (or sometimes RNA) that is coated in protein that allows it to invade cells. Once inside, the DNA can hijack your cell's machinery to make a ton of copies of the virus (DNA + protein capsid). Our immune systems try to recognize specific sequences in the protein capsid. Once they've learned a specific sequence, immune cells are very efficient at eliminating virus before it can infect cells and spread in your body.

Protein synthesis normally goes from DNA -> RNA -> protein. With the mRNA vaccine, we are jumping the line and giving just the RNA, but not all the RNA, just a specific piece that is the spike protein. This has the nice advantage that the RNA can't replicate itself, so it's one-and-done. It'll produce some protein in your body, just enough that your immune system can learn some specific sequence that'll let it eliminate the entire virus should you encounter it.

Normally if you inject RNA in your body, it will never make it into a cell. It isn't stable enough and won't cross the cell barrier. Instead, as Boris said, pharmaceutical companies and scientists have figured out a way to package the mRNA in a fatty capsule that is stable and efficiently carries the mRNA into cells.

As for your other question -- yes. There have been dozens (and now over a hundred) trials using mRNA vaccines. Moderna has been working on their fatty capsule for a long time and done lots of clinical trials to choose the optimal formulation. So this has been tested for years already, under very close FDA supervision.
Thanks for the replies. I'm trying not to blank out when I explain these things to people. I don't want to not have an answer for anything they are worried about.
So I know how to explain the process of Mrna but how do I explain in a quick 1,2 punch where the fatty capsule, mrna and protein that are in the vaccine come from? Are they just made in a lab from scratch? They have to come from something.
 
Thanks for the replies. I'm trying not to blank out when I explain these things to people. I don't want to not have an answer for anything they are worried about.
So I know how to explain the process of Mrna but how do I explain in a quick 1,2 punch where the fatty capsule, mrna and protein that are in the vaccine come from? Are they just made in a lab from scratch? They have to come from something.
Any specific genetic sequence you want can be made (for the mRNA) by just sending a sequence off to a lab. More likely, they probably purified the desired segment of the mRNA from the virus itself and then amplified just that portion. This can be done with incredibly high fidelity.

The fatty capsule (lipid nanoparticle) is made through a series of chemical reactions and purification steps. The exact process is beyond my level of understanding but these are technologies that have been around for decades and are produced with strict standards of purity.

The vaccine doesn't have any protein in it. It just induces your body to make some of the protein itself.

This article has a longer discussion and explains how lipid nanoparticles have been around for years. One study screened 300 different lipids to come up with the optimal one.


So my 1-2 punch would be: we can isolate and copy the mRNA very effectively using genetic technology and then scientists have optimized a way to mix this mRNA with lipids to produce small packages that can get the mRNA to your cells cleanly. All of this is established technology that has been carefully tested for a long time before covid-19 to find just the right mix. And at each step there are very strict checks for purity that go well beyond typical manufacturing standards. The only new thing they did was covid-19 was choosing which portion of the virus protein to use for the mRNA.
 
Any specific genetic sequence you want can be made (for the mRNA) by just sending a sequence off to a lab. More likely, they probably purified the desired segment of the mRNA from the virus itself and then amplified just that portion. This can be done with incredibly high fidelity.

The fatty capsule (lipid nanoparticle) is made through a series of chemical reactions and purification steps. The exact process is beyond my level of understanding but these are technologies that have been around for decades and are produced with strict standards of purity.

The vaccine doesn't have any protein in it. It just induces your body to make some of the protein itself.

This article has a longer discussion and explains how lipid nanoparticles have been around for years. One study screened 300 different lipids to come up with the optimal one.


So my 1-2 punch would be: we can isolate and copy the mRNA very effectively using genetic technology and then scientists have optimized a way to mix this mRNA with lipids to produce small packages that can get the mRNA to your cells cleanly. All of this is established technology that has been carefully tested for a long time before covid-19 to find just the right mix. And at each step there are very strict checks for purity that go well beyond typical manufacturing standards. The only new thing they did was covid-19 was choosing which portion of the virus protein to use for the mRNA.
I'm about to copy and paste that summary into a text message. Hopefully they understand that.
 
I traveled this past weekend and it looks like it's all back to pre-pandemic levels, or even more. At least people are wearing masks in public (usually) but I'm sure many of these crowds are hanging out in private too.

If we don't see a surge this month, then I'd say the vaccine is working well to limit spread. But I doubt it'll be enough to stamp this out. This virus will linger and circulate for a while.
 
I traveled this past weekend and it looks like it's all back to pre-pandemic levels, or even more. At least people are wearing masks in public (usually) but I'm sure many of these crowds are hanging out in private too.

If we don't see a surge this month, then I'd say the vaccine is working well to limit spread. But I doubt it'll be enough to stamp this out. This virus will linger and circulate for a while.
Took my son to the orthodontist this morning for a consultation (was previously scheduled for last March, but cancelled when the world shut down) and scheduled the first appointment when they opened at 8am thinking it would be empty. It’s the first time I’ve been to any medical office for a while and other than a note on the door saying masks were required it was almost as if there was no pandemic. Waiting room was full-ish and all 6 procedure chairs (in one big open room) were full. Staff were masked, but obviously patients were all unmasked with mouths wide open. They tried having my son take his mask off and leave it off but I told them he would only take it off when necessary for pics and x-rays. We were both uncomfortable with the situation. Dude needs braces, but how long do we put it off, considering kids probably won't be vaccinated until the end of 2021 or early 2022...
 
Blake P Blake P I feel the same way, but i've been taking my kiddo to dentist and ortho office few times, even last year, and so far we've been OK. She'll have follow up apt in the next few weeks to check on the braces. I personally also had my teeth cleaning done early this year and last year. At least my dentist office are using face shield in addition to surgical mask.
 
Many police officers spurn coronavirus vaccines as departments avoid mandates
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Glen Ridge Police Department officers wear protective face masks as they salute the funeral procession of their fellow officer Charles Roberts, after the 45-year-old father of three died of the coronavirus disease (COVID-19) in Glen Ridge, New Jersey, U.S., May 14, 2020. REUTERS/Mike Segar
Isaac Stanley-Becker
Sun, May 2, 2021, 3:45 PM


Police officers were among the first front-line workers to gain priority access to coronavirus vaccines. But their vaccination rates are lower than or about the same as those of the general public, according to data made available by some of the nation's largest law enforcement agencies.
The reluctance of police to get the shots threatens not just their own health but the safety of people they're responsible for guarding, monitoring and patrolling, experts say.
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At the Las Vegas Metropolitan Police Department, 39% of employees have gotten at least one dose, officials said, compared to more than 50% of eligible adults nationwide. In Atlanta, 36% of sworn officers have been vaccinated. Twenty-eight percent of those employed by the Columbus Division of Police - Ohio's largest police department - report having received a shot.

"I think it's unacceptable," Joe Lombardo, the head of Las Vegas police and sheriff of Clark County, said of the demand for the shots within his force.
The numbers paint a troubling picture of policing and public health. Because officers have high rates of diabetes, heart disease and other conditions, their hesitancy puts them at greater risk of serious illness from the coronavirus while undermining force readiness, experts said. Police officers were more likely to die of covid-19, the illness that can be caused by the novel coronavirus, last year than of all other causes combined, according to data compiled by the National Law Enforcement Officers Memorial Fund.
Police hesitancy also means officers may be vectors of spread to vulnerable people with whom they interact during traffic stops, calls for service and other high-contact encounters. That could thwart efforts to restore community trust in a moment of heightened scrutiny after last month's conviction of ex-officer Derek Chauvin in the killing of George Floyd.
"Police touch people," said Sharona Hoffman, a professor of law and bioethics at Case Western Reserve University. "Imagine having a child in the car who's not vaccinated. People would want to know if a police officer coming to their window is protected."
Police ambivalence about immunization finds a parallel among other front-line workers. Fifty-two percent of health-care workers surveyed by The Washington Post and the Kaiser Family Foundation between Feb. 11 and March 7 said they had received at least one dose.
One solution is for departments to make vaccination compulsory, according to experts in bioethics and public health, just as some health-care settings and institutions of higher education have begun doing.
But department leaders and union officials said in interviews that such requirements could backfire or lead to lengthy litigation. Of more than 40 major metropolitan police departments contacted by The Post, none had made vaccination compulsory for employees.
That reflects a belief among officers - and their unions - that getting a shot is a private decision.
"I hate to sound like I don't care, but I really don't," Vince Champion, the Atlanta-based Southeast region director of the International Brotherhood of Police Officers, said of low vaccination rates. "It's a personal decision. We fight [the virus] every day. We're out among every disease in the world."
Authorities in roughly half the departments, from Philadelphia to Houston to San Francisco, were not tracking how many of their officers were vaccinated. That baffled Chris Cosgriff, executive director of the Officer Down Memorial Page, which honors law enforcement officers killed in the line of duty.
Commanders should know whether officers are vulnerable to "getting sick and potentially dying," he said. "It's a readiness issue."
- - -
Hesitancy within police departments is rooted in some of the same concerns expressed by the general public, according to police chiefs, union officials and experts in policing and public health.
Officers have voiced unease about the novelty of the shots and the speed with which they were developed, along with confidence that they can avoid the virus with proper protective gear. The majority of police are men, who are less likely than women to be immunized.
Many officers also reject immunization because they think previous covid-19 infections have given them immunity, said Sean Smoot, director and chief legal counsel of the Police Benevolent and Protective Association of Illinois. That assumption runs counter to federal health guidance, which indicates that recovered people should be vaccinated because the duration of post-infection protection is unknown.
Some of the differences in police uptake of the vaccine reflect disparities among the communities they serve. Hawaii, where 80% of officers in Honolulu have received at least one dose, has administered more doses per capita than all but four states, and the Democratic governor, David Ige, has moved forward with plans for certifications known as vaccine passports, a cousin of vaccine mandates. A greater proportion of residents in Denver County, Colo., are vaccinated than in, for example, Clark County, Nev., which includes Las Vegas, or Fulton County, Ga., which includes Atlanta.
Smaller cities report lower rates of police vaccination. Twenty percent of officers in Mobile, Ala., have been vaccinated, said the city's public safety director, Lawrence Battiste. Some may have gotten their shots without the help of the city, he said, and therefore have gone untracked. But many are young, he said, and think the vaccines may be linked to infertility, an idea spread on social media that experts say has no basis in fact.
Amid such concerns, a few police departments stand out for their success.
In Denver, the police chief joined the president of the city's police union in July to enroll in a clinical trial of Moderna's vaccine at UC Health, along with more than a dozen officers. The chief, Paul Pazen, received the placebo but got the real thing in the early days of the vaccine rollout in December, when police gained priority access along with other emergency workers.
Sixty-nine percent of Denver's Public Safety Department has been vaccinated, Pazen said, at clinics run at the city's crime lab and at a sheriff's department training facility. That's among the highest rates disclosed by departments contacted by The Post.
"That's not an accident," the chief said. By the time those vaccine clinics opened, he said, his officers had learned about mRNA - the technology behind the Moderna and Pfizer-BioNTech vaccines - and had seen a video of the union president discussing his experience in the trial. "I would do it again," the union president, Nick Rogers, says in the video, which was provided to The Post.
Pazen says too many departments waited to urge staffers to get immunized. "Other places are struggling," he said.
Some cities are turning to incentives to boost participation. The Phoenix Police Department is offering a one-time $75 vaccine safety award to employees who get protected. Nine-hundred-nineteen employees, out of 3,982 total, have submitted a completed vaccine card to receive the rewards, said a city spokesman, Dan Wilson.
Other places are using inducements of other kinds. To spur interest in the vaccines, Lombardo, the chief in Las Vegas, revoked a policy at the beginning of April that had treated all coronavirus infections as work-related. Now officers must use their own sick leave to quarantine and recuperate. But the order has had little effect, he said, because more than 30 employees have tested positive since.
Lombardo said he has also sought to make vaccination more accessible by offering shots in briefing rooms and jails. "I'm doing everything I can to make it readily available, but I hire from the human race, and sometimes people are just lazy."
Steve Grammas, a Las Vegas detective and president of the city's police union, dismissed the notion that laziness is the issue. Those who have refrained, he said, may simply be uninterested.
"It's a personal choice that everyone's going to make," he said.
Committed to that view of vaccination as a personal matter, officials in scores of large cities said they are not tracking vaccinations. "Because it's strictly voluntary, we prefer not to intrude in privacy issues," said Alvaro Zabaleta, a detective with the Miami-Dade Police Department in Florida.
Other departments have partial records. In Chicago, officers who received shots at department clinics, or who used a specific code to sign up as emergency workers beginning in January, number at least 4,000, out of 12,413 active officers, city officials said. But many may have gotten shots elsewhere.
The San Antonio Police Department stopped keeping count in late January, when eligibility expanded and officers began getting vaccinated on their own. At that point, 50% of officers had received shots, said Christopher Ramos, a department spokesman.
Jason Pappas, an officer in Columbus, said the department's numbers may skew low because law enforcement in Ohio only became eligible for the shots in March, months later than in neighboring states. That delay stirred anger and may now be causing officers to withhold their vaccination status, he said.
Limited data makes it impossible to know whether mandates are appropriate, said Noel Brewer, a professor of public health behavior at the University of North Carolina.
"Requirements are best put into place once the behavior is already relatively common," he said. "Otherwise you can get immediate blowback."
- - -
The experience of the few law enforcement agencies requiring employees to be vaccinated illustrates why such decisions are often fraught.
Mandates issued in January for employees of the sheriff's office in Durham County, N.C., and emergency workers in Doña Ana County, N.M., prompted federal lawsuits contending that vaccines authorized for emergency use cannot be made a condition of employment.
The claims cite language from the Food and Drug Administration's fact sheet describing coronavirus immunization as a "choice," as well as assurances from federal health officials that "vaccines are not allowed to be mandatory." The complaint of a Durham County sheriff's deputy, who was dismissed after he refused to provide proof of vaccination, says he was confronted with "the Hobson's choice of either being forced to take an experimental, unapproved vaccine against his will, or being fired, stigmatized, and having his life upended."
Mandatory vaccination, especially for police, is politically charged. The dispute in Durham County gained notice in the right-wing media, where a Facebook page called "Thin Blue Line" posted a January article criticizing the requirement as "communism" in a group with more than 73,000 members titled "We Support Our Police."
Vaccine mandates probably would pass legal muster, according to specialists in employment law, providing that they adhere to guidance issued last year by the U.S. Equal Employment Opportunity Commission outlining exceptions for disability and religious belief. The broad authority of states and localities to protect public welfare would encompass compulsory vaccination of police, said Catherine Ruckelshaus, legal director of the National Employment Law Project.
But most police leaders see the legal and union fights as minefields they'd rather avoid. "We have made a very deliberate decision not to mandate it for staff," said Joseph Chacon, chief of the Austin Police Department, who has refrained from questioning officers about their immunization status, saying they have "trepidation in thinking we might be trying to track that somehow, which we're not."
Pazen, the chief in Denver, said he fears the legal ramifications of a mandate and would "prefer to get voluntary compliance."
Vaccine policy has generated intense discussion within the Major Cities Chiefs Association, said Lombardo, the Las Vegas police official. The "decision point" that would trigger a mandate for his department, he said, is a rate of coronavirus infection that would leave his force without "sufficient employees to address calls for service."
"I haven't been put into that position yet," he said.
Some officers say talk of mandates is premature. More than half of the Los Angeles Police Department has received at least one dose, said Mark Cronin, a 27-year veteran of LAPD and a union official handling virus-related issues.
Most of the questions he fields are from officers asking how to decide among the three authorized vaccines, how to arrange their vaccination and how to plan for a booster shot, he said.
And for officers who refuse vaccination, Cronin's message is blunt. "I tell our members that you're an absolute fool if you don't get it."

Many police officers spurn coronavirus vaccines as departments avoid mandates (yahoo.com)
 
Got my 2nd shot of Moderna last Thursday and was expecting for the symptoms a lot of people experienced, but luckily, I just felt really tired and napped.

My allergies were a bigger issue the past two days.

Divin, dippin, and dodgin COVID for a year only to get taken out by pollen.
 
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