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I have a couple of relatives who were holding out on the vaccine. Wonder what they’re going to do now and I wish I could be there when they heard the news
Hide Ya Wives, Hide Ya Kids: Worldwide Coronavirus Pandemic!
kdawg
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Apparently my resistant father-in-law is there right now getting a booster - he's been listening to Joe Rogan and going on about natural immunity for a while but seems to have been persuaded finally. I'm not supposed to tell anyone as he wants to surprise the family so shhh.
At my shift in the vaccine clinic this weekend I saw quite a few 20-30s getting their first dose - kind of just resigned to before they need proof to go anywhere so at least that's working.
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I come in Peace: Have there been any official studies proving that a booster is necessary after 6-8 months.
Is there hard evidence backing this waning immunity theory and not just the fact that a lot people have contracted Covid after being fully vaccinated.
Is there hard evidence backing this waning immunity theory and not just the fact that a lot people have contracted Covid after being fully vaccinated.
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There's been a strong correlation between Israel's Delta surge and the booster campaign that crushed it. If you're young and healthy and have gotten 2 doses you're probably still well protected against severe disease and death, but the benefits of getting boosted far outweigh the risks, IMO. Based on what I've seen and heard from reputable/trusted sources, you shouldn't be considered fully vaccinated until you've had 3 doses.
Air Champa
formerly champa
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Sadly, there has been a pretty incredible rise in hospitalizations among the 0-5 age group, with some reports of more severe disease among these children. Hopefully it's just parents being extra cautious, but early reports don't look good.
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First time I've heard this explanation, but it makes sense. Gottlieb states that Pfizer found the downside of a variant specific booster for COVID is that although it likely provides better immune response against the targeted variant, it doesn't seem to give as broad of an immune response against other strains of the virus that are either circulating simultaneously or that will undoubtedly come afterward.
kdawg
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I think that makes sense - and it’s basically the argument I use against “natural immunity” - yes you’ll have antibodies, but only to a specific strain rather than the broad protection of the vaccine - as long as the virus doesn’t mutate away from the specific characteristic the vaccine is effective against.
It’s also related to the reason why you need a flu shot each year - immunity from prior infection doesn’t help against other strains. Doesn’t mean the vaccine is ineffective it’s just the nature of a virus like that.
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Please entertain my layman's question about so-called "natural immunity" being less effective against variants. If getting infected provides antibodies against S(pike), N(ucleocapsid), and E(nvelope) proteins and vaccine only provides antibodies against S, wouldn't infection induced immunity theoretically be better because it provides a wider array of antibodies in case a variant changes enough? In the case of Omicron, the spike has mutated pretty significantly, but maybe N and E are still recognized? Sorry if this doesn't make sense, but I never took any science classes after high school.
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almost 24 hours after my blue chip boost. arm is more tender than the first shot. some symptoms but way more mild than the second shot. tiredness and general feeling blah. about a 2/10 in terms of severity.
kdawg
Staff member
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Thanks
kdawg
Yeah, I understand all that in theory, but my question was more specifically directed toward the fact that your immune system would potentially be able to target more parts of the virus after an infection since it was exposed to the WHOLE virus rather than just the spike. Trust me, I am avoiding infection at all costs. I guess I'm wondering why successful vaccine manufacturers (except Sinopharm and Sinovac?) seem to have targeted the spike rather than including various other parts of the virus. I'm sure the explanation would likely be more complicated than something I would be able to understand easily anyway. Cheers mate!
kdawg
Yeah, I understand all that in theory, but my question was more specifically directed toward the fact that your immune system would potentially be able to target more parts of the virus after an infection since it was exposed to the WHOLE virus rather than just the spike. Trust me, I am avoiding infection at all costs. I guess I'm wondering why successful vaccine manufacturers (except Sinopharm and Sinovac?) seem to have targeted the spike rather than including various other parts of the virus. I'm sure the explanation would likely be more complicated than something I would be able to understand easily anyway. Cheers mate!
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so you got me thinking and I tried looking up different sources to these questions but I got nowhere and ended up on wikipedia
this is coronavirus (SARS-CoV 2). the 4 proteins are the structural proteins, theres a bunch more that work in the actual virion.
this is the simplified life/replication cycle of an RNA virus (RNA viruses duplicate in the cytoplasm, DNA in the nucleus. coronavirus is an RNA virus).
so the spike protein S attacks step 1: attachment. widely studied, vaccines work, etc etc.
the envelope protein E provides an outer layer of protection to some viruses. wikipedia says it functions in step 5: assembly. more research needs to be done.
Coronavirus envelope protein - Wikipedia
Coronavirus envelope protein: current knowledge - Virology Journal
Background Coronaviruses (CoVs) primarily cause enzootic infections in birds and mammals but, in the last few decades, have shown to be capable of infecting humans as well. The outbreak of severe acute respiratory syndrome (SARS) in 2003 and, more recently, Middle-East respiratory syndrome...
virologyj.biomedcentral.com
the nucleocapsid protein N also works in step 5: assembly. apparently for protein interactions also. apparently vaccines that target S and N have been studied are good for extreme disease where the brain is affected, and also for post-infection complications
Coronavirus nucleocapsid protein - Wikipedia
Combining spike- and nucleocapsid-based vaccines improves distal control of SARS-CoV-2
SARS-CoV-2 infection causes respiratory insufficiency and neurological manifestations, including loss of smell and psychiatric disorders, and can be f…
Spike-based COVID-19 immunization increases antibodies to nucleocapsid antigen
Antibodies to the nucleocapsid (N) antigen are suggested to be used to monitor infections after COVID-19 vaccination, as first generation subunit vacc…
theres a 4th protein, membrane protein M. membranes are inner layers of protection, and this protein also works in step 5: assembly. not much/anything about it for a vaccine though.
Coronavirus membrane protein - Wikipedia
so just based off of my own speculation, the spike protein is the primary target since it attacks so early in the replication/infection cycle while the other proteins operate later down the line. avoids any potential complications or responses to any viral material that isn't marked for cell death.
tl;dr there are 4 coronavirus structural proteins. spike is the most infamous, and the target of most/all of the vaccines. it works at step 1 of the viral replication cycle. the others dont. more research needs to be done.
editors note: an hour+ of not doing actual IRL work FTW
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got my 10 year old his first shot today. Wife, oldest son, and I all received our 2nd dose months ago, and he was going raw dog.
Been looking to get a booster everywhere. Earliest appointment I could find was mid Jan.
Asked the place where my son was getting his shot if they were doing boosters."Yes sir! But only Pfizer."
I'll be damned. Got lucky. Called the wife to come through. She's activated now. Called my boss as well, since he lives near me and was close to the facility. he got hooked up. Brownie points.
Feels good. But mostly because my youngest got his first shot. He's been living in fear and takes his mask wearing very seriously. Even has the mask tan on his face.
Been looking to get a booster everywhere. Earliest appointment I could find was mid Jan.
Asked the place where my son was getting his shot if they were doing boosters."Yes sir! But only Pfizer."
I'll be damned. Got lucky. Called the wife to come through. She's activated now. Called my boss as well, since he lives near me and was close to the facility. he got hooked up. Brownie points.
Feels good. But mostly because my youngest got his first shot. He's been living in fear and takes his mask wearing very seriously. Even has the mask tan on his face.
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haha, my kids too!
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So now we have the new variant coming. Don’t even know what to think of it
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auto play + dramatic music 
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RustyShackleford
Supporter
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I was reading the anti-vax supplement stack thinking "Damn, no colloidal silver? I thought loony health nuts love that ****"
Got down to the nebulizer section and...
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They want to force this "vaccine" on you but don't want to tell you about these 30 other things with countless chemicals that you can use to help possibly, maybe, might/might not endure it.
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Don't think I've taken that many dr prescribed pharmaceuticals in my life
Stew Peters sounds like something they eat in the UK or Northern Europe
Stew Peters sounds like something they eat in the UK or Northern Europe
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Stew Peters followed by some Spotted ****.
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Mans got:
Pink eye, heartburn, high cholesterol, asthma, parasites, allergies, malaria, and COPD on top of all the vitamins and heavy metals on that list
Pink eye, heartburn, high cholesterol, asthma, parasites, allergies, malaria, and COPD on top of all the vitamins and heavy metals on that list
