“The stimulant hypoxanthine, not any special properties of its protein, vitamins, or minerals is responsible for the satisfying and stimulating effects of meat. It is similar in chemical formula and effect as caffeine.
It has been known since antiquity that those who regularly eat meat experience some degree of enervation when they are deprived of this food for some time. This sensation that “something is missing” always results from abruptly removing meat from the diet, even when it is replaced with plant foods and dietary supplements providing as much or even more protein and nutrients as meat.
Today it’s known that the muscle cells of meat contain Hypoxanthine, which increases in concentration as the meat ages.
Hypoxanthine and other similar substances, such as inosinic acid and guanylic acid, are present in meat. They have a chemical structure similar to that of caffeine in coffee or the theobromine in cocoa, with similar effects. They are central nervous system stimulants. They are addictive.
Hypoxanthine explains the stimulating effect of meat and it’s capacity to create a certain level of addiction, which manifests itself when meat is given up abruptly. Because of this, it is recommended that those wishing to replace meat with plant-based foods follow a transition diet to help avoid the effect of sudden deprivation.